Cancer testing technology and saccharin
نویسندگان
چکیده
منابع مشابه
Is saccharin safe? Animal testing revisited.
The ability to predict harmful effects of chemicals, drugs, and food additives has historically depended on the process of extrapolating from animal studies. The current guidelines of the U.S. Food and Drug Administration recommend nine animalbased studies to assess the safety of additives used directly in food handling or preparation or at the table in amounts in excess of 1 part per million i...
متن کاملCancer mortality and saccharin consumption in diabetics.
The mortality experience of 5971 members of the British Diabetic Association (BDA) was followed-up for between five and eight years to mid-1973. Overall, 1207 deaths occurred compared with 778 expected from the mortality of the population of England and Wales in 1972. This excess of deaths was due almost entirely to diabetes mellitus and ischaemic heart disease. Deaths from cancer (128) were si...
متن کاملSaccharin and Its Salts
Saccharin Chem. Abstr. Serv. Reg. No.: 81-07-2 Deleted CAS Reg. Nos: 474-91-9; 61255-27-4; 126987-83-5 Chem. Abstr. Name: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide IUPAC Systematic Name: 1,2-Benzisothiazolin-3-one, 1,1-dioxide Synonyms: Acid saccharin; anhydro-ortho-sulfaminebenzoic acid; 3-benzisothiazolinone 1,1-dioxide; benzoic sulfimide; benzoic sulphinide; benzosulfimide; benzosulfinide; o...
متن کاملGenotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin.
Low-calorie sweeteners are chemicals that offer the sweetness of sugar without the calories. Consumers are increasingly concerned about the quality and safety of many products present in the diet, in particular, the use of low-calorie sweeteners, flavorings, colorings, preservatives, and dietary supplements. In the present study, we evaluated the mutagenicity of the three low-calorie sweeteners...
متن کاملReproductive toxicology. Sodium saccharin.
The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative bacteria and forms part of the innate immune response in mammals. Like other class 1 receptors, TLR4 is activated by ligand induced dimerization, and recent studies suggest that ...
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ژورنال
عنوان ژورنال: Food Policy
سال: 1978
ISSN: 0306-9192
DOI: 10.1016/0306-9192(78)90031-3